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Cover Picture: Photophysical and Duplex‐DNA‐Binding Properties of Distamycin Dimers Based on 4,4′‐ and 2,2′‐Dialkoxyazobenzenes as the Core (Chem. Asian J. 11/2008)
Author(s) -
Ghosh Sumana,
Usharani Dandamudi,
De Susmita,
Jemmis Eluvathingal D.,
Bhattacharya Santanu
Publication year - 2008
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200890033
Subject(s) - azobenzene , moiety , chromophore , chemistry , stereochemistry , tetrapeptide , isomerization , dna , molecule , duplex (building) , conjugate , covalent bond , crystallography , photochemistry , biochemistry , peptide , mathematical analysis , mathematics , organic chemistry , catalysis
Light‐induced isomerization of azobenzene is accompanied by significant changes in the geometry and polarity of a chromophore. S. Bhattacharya et al. covalently tether a distamycin‐based tetrapeptide to both ends of a central dihydroxyazobenzene moiety at either the 2,2' or 4,4' positions. This affords two isomeric, distamycin–azobenzene–distamycin systems, both being photoisomerizable. The findings from an experimental investigation are substantiated by using molecular‐docking studies involving each conjugate with a model duplex d[(GC(AT) 10 CG)] 2 DNA molecule. For more information, see their Full Paper on page 1949 ff.