Premium
Photodynamic Activity of C 70 Caged within Surface‐Cross‐Linked Liposomes
Author(s) -
Ikeda Atsushi,
Nagano Mai,
Akiyama Motofusa,
Matsumoto Masashi,
Ito Sayuri,
Mukai Masaru,
Hashizume Mineo,
Kikuchi Junichi,
Katagiri Kiyofumi,
Ogawa Takuya,
Takeya Tatsuo
Publication year - 2009
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200800271
Subject(s) - liposome , hela , lysis , chemistry , photodynamic therapy , drug , drug delivery , membrane , drug carrier , biophysics , pharmacology , biochemistry , medicine , cell , biology , organic chemistry
[70]Fullerene (C 70 ) encapsulated into a surface‐cross‐linked liposome, a so‐called cerasome, was prepared by an exchange reaction incorporating C 70 ⋅γ‐cyclodextrin complexes into lipid membranes. Fullerene exchange in a cerasome‐incorporated C 70 (CIC 70 ), as well as in a lipid‐membrane‐incorporated C 70 (LMIC 70 ), was completed within 1 min with stirring at 25 °C. CIC 70 was more resistant to lysis than LMIC 70 towards lysing agents such as surfactants. Furthermore, the photodynamic activity of CIC 70 in HeLa cells was similar to that of LMIC 70 , indicating that C 70 can act as a photosensitizing drug (PS) without release from cerasome membranes. Thus, in contrast with general drug‐delivery systems (DDSs), which require the drug to be released from the interior of liposomes, carriers for PSs for use in photodynamic therapy (PDT) do not necessarily need to release the drug. These results indicate that DDSs with high morphological stability can increase the residence time in blood and achieves tumor‐selective drug delivery by the enhanced permeability and retention (EPR) effect.