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Highly Enantioselective Copper‐Catalyzed Ring Opening of Oxabicyclic Alkenes with Grignard Reagents
Author(s) -
Zhang Wei,
Zhu ShouFei,
Qiao XiangChen,
Zhou QiLin
Publication year - 2008
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200800159
Subject(s) - enantioselective synthesis , reagent , phosphine , catalysis , grignard reagent , chemistry , ring (chemistry) , copper , organic chemistry , combinatorial chemistry , medicinal chemistry
A highly efficient copper‐catalyzed enantioselective ring opening of oxabicylic alkenes with Grignard reagents has been developed by using chiral spiro phosphine ligands. Excellent trans selectivities, good yields, and high enantioselectivities are obtained for a broad range of Grignard reagents under mild reaction conditions. The catalyst system shows an extraordinary activity and the TON of the reaction reaches 9000.