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Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents
Author(s) -
Peacock Anna F. A.,
Sadler Peter J.
Publication year - 2008
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200800149
Subject(s) - osmium , ruthenium , chemistry , group 2 organometallic chemistry , reactivity (psychology) , combinatorial chemistry , anticancer drug , organometallic chemistry , metal , dendrimer , nanotechnology , organic chemistry , molecule , drug , catalysis , materials science , pharmacology , medicine , alternative medicine , pathology
The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon‐bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure–activity relationships and elucidation of the speciation of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of ruthenium and osmium arene complexes as anticancer agents are discussed.