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Rhodium‐Catalyzed Asymmetric Addition of Terminal Alkynes to Diarylphosphinylallenes
Author(s) -
Nishimura Takahiro,
Guo XunXiang,
Hayashi Tamio
Publication year - 2008
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200800042
Subject(s) - rhodium , protonolysis , catalysis , terminal (telecommunication) , catalytic cycle , chemistry , enantioselective synthesis , stereochemistry , medicinal chemistry , organic chemistry , computer science , telecommunications
The presence of an acid was found to be essential in the rhodium‐catalyzed asymmetric addition of terminal alkynes to diarylphosphinylallenes giving exo ‐enynes in high yields with high regio‐ and enantioselectivity. The stereochemical outcome is determined at the protonolysis of the π‐allylrhodium(I) intermediate involved in the catalytic cycle.