Premium
Hydrogen‐Bond‐Mediated Asymmetric Catalysis
Author(s) -
Yu Xinhong,
Wang Wei
Publication year - 2008
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200700415
Subject(s) - organocatalysis , electrophile , catalysis , chemistry , combinatorial chemistry , hydrogen bond , enantioselective synthesis , organic synthesis , organic chemistry , nanotechnology , materials science , molecule
The utilization of hydrogen bonding as an activation force has become a powerful tool in asymmetric organocatalysis. Significant advances have been made in the recent past in this emerging field. Due to space constraints, this Focus Review summarizes only the key aspects with an emphasis on catalysis based on chiral ureas and thioureas, diols, and phosphoric acids. The examples provided neatly demonstrate that chiral ureas and thioureas, diols, and phosphoric acids display effective and unique activation modes of catalysis for a broad spectrum of asymmetric organic transformations, including single‐step and multiple‐step cascade reactions. These functionalities, which have the ability to afford efficient H‐bond activation of electrophiles including CO, CN, aziridines, and epoxides, have established their status as “privileged” functional groups in the design of organocatalysts.