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Functional Near‐Infrared Fluorescent Probes
Author(s) -
Kiyose Kazuki,
Kojima Hirotatsu,
Nagano Tetsuo
Publication year - 2008
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200700267
Subject(s) - fluorescence , near infrared spectroscopy , biomolecule , absorption (acoustics) , chemistry , biophysics , nanotechnology , materials science , optics , biology , physics , composite material
Near‐infrared (NIR) fluorescent probes have attracted much attention, but despite the availability of various NIR fluorophores, only a few functional NIR probes, that is, probes whose absorption and/or fluorescence spectra change upon specific reaction with biomolecules, have been developed. However, functional probes operating in the NIR range that can be targeted to protons, metal ions, nitric oxide, β‐galactosidase, and cellular stress markers are expected to be effective for fluorescence imaging in vivo. This Focus Review concentrates on these functional NIR probes themselves, not their applications.