Premium
Metal Vinylidenes as Catalytic Species in Organic Reactions
Author(s) -
Trost Barry M.,
McClory Andrew
Publication year - 2008
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200700247
Subject(s) - pericyclic reaction , nucleophile , electrophile , metal , catalysis , organic reaction , organic synthesis , ligand (biochemistry) , chemistry , photochemistry , combinatorial chemistry , organic chemistry , biochemistry , receptor
Abstract Organic vinylidene species have found limited use in organic synthesis owing to their inaccessibility. In contrast, metal vinylidenes are much more stable and may be readily accessed through transition‐metal activation of terminal alkynes. These electrophilic species may be trapped by a number of nucleophiles. Additionally, metal vinylidenes can participate in pericyclic reactions and processes that involve migration of a metal ligand to the vinylidene species. This Focus Review addresses the reactions and applications of metal vinylidenes in organic synthesis.