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Structural Selection in G‐Quartet‐Based Hydrogels and Controlled Release of Bioactive Molecules
Author(s) -
Sreenivasachary Nampally,
Lehn JeanMarie
Publication year - 2008
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200700041
Subject(s) - self healing hydrogels , hydrazide , chemistry , supramolecular chemistry , guanosine , molecule , guanine , combinatorial chemistry , controlled release , nanotechnology , organic chemistry , biochemistry , materials science , nucleotide , gene
Abstract A guanosine‐5′‐hydrazide can entrap biologically interesting molecules such as acyclovir, vitamin C, and vancomycin into its hydrogel network. Controlled release of these molecules was monitored by 1 H NMR spectroscopy. The hydrazide may potentially form mixed G–G quartets with analogous compounds containing a guanine group. 1 H NMR spectroscopy was used to study the inclusion of various guanine derivatives into the hydrogel. The structural selectivity was found to depend strongly on both the shape and the charge of the additive and may arise from the strong cohesion of the supramolecular architecture of the gel and the resulting resistance to perturbation by foreign bodies. Hydrogels thus offer a promising medium for highly selective, controlled release of bioactive substances.