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Cover Picture: A Method of Orthogonal Oligosaccharide Synthesis Leading to a Combinatorial Library Based on Stationary Solid‐Phase Reaction (Chem. Asian J. 6/2006)
Author(s) -
Ako Takuro,
Daikoku Shusaku,
Ohtsuka Isao,
Kato Rumiko,
Kanie Osamu
Publication year - 2006
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200690013
Subject(s) - cover (algebra) , anomer , monosaccharide , combinatorial chemistry , glycosylation , solid phase synthesis , stationary phase , oligosaccharide , phase (matter) , computer science , chemistry , stereochemistry , organic chemistry , engineering , chromatography , biochemistry , mechanical engineering , peptide
Libraries not of books but of oligosaccharides have potentially important applications in medicine and the pharmaceutical industry. However, the building of these libraries is hindered by lengthy protocols and specific reaction conditions that cannot be applied generally. In response to these issues, Kanie and co‐workers developed an efficient synthetic strategy based on a combination of solid‐phase reaction and orthogonal glycosylation, in which monosaccharides are coupled to each other step by step to form anomeric combinations of oligosaccharides. Find out more in their Full Paper on page 798 ff.