In Situ Generation of Chiral N ‐Dienyl Lactams in a Multicomponent Reaction: An Efficient and Highly Selective Way to Asymmetric Amidocyclohexenes

Chiral N ‐dienyl lactams are crucial building blocks for the synthesis of complex organic compounds. However, their generation is rather challenging. This paper reports on a highly efficient and diastereoselective multicomponent methodology utilizing chiral a mides, a ldehydes, and d ienophiles (AAD reaction). The three components readily react under in situ generation of chiral N ‐dienyl lactams which undergo a subsequent Diels–Alder reaction. Different chiral amides have been employed in the standard protocol delivering yields up to 94 %, and selectivities up to 90 % de . Moreover, DFT calculations were performed to explain the obtained selectivities.