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Chemoselective C(sp 3 )H Bond Activation for the Preparation of Condensed N‐Heterocycles
Author(s) -
Ren Hongjun,
Li Zhuo,
Knochel Paul
Publication year - 2007
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200600398
Subject(s) - phenanthridine , intramolecular force , pyrrole , chemistry , ring (chemistry) , medicinal chemistry , catalysis , stereochemistry , combinatorial chemistry , organic chemistry
Condensed N‐heterocycles were prepared by using CH activation reactions catalyzed by Pd(OAc) 2 (5 mol %) and ( p ‐tolyl) 3 P (10 mol %). The key step of these ring closures is chemoselective intramolecular CH activation of the methyl group at position 2 of the pyrrole ring. Functionalized 9 H ‐pyrrolo[1,2‐a]indoles and pyrrolo[1,2‐f]phenanthridine derivatives were prepared in good yields. The preparation of some complex N‐heterocycles by using successive reactions is also described.