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Total Synthesis of Lactacystin and Salinosporamide A
Author(s) -
Shibasaki Masakatsu,
Kanai Motomu,
Fukuda Nobuhisa
Publication year - 2007
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200600310
Subject(s) - lactacystin , proteasome , chemistry , combinatorial chemistry , computational biology , nanotechnology , proteasome inhibitor , biology , biochemistry , materials science
Lactacystin and salinosporamide A are fascinating molecules with regard to both their chemical structures and biological activities. These naturally occurring compounds are potent and selective proteasome inhibitors. The molecular structures are characterized by their densely functionalized γ‐lactam cores. The structure and biological properties of these two compounds are attracting the attention of many chemists as challenging synthetic targets. We discuss their synthetic strategies in this review.