Premium
A Formal Total Synthesis of Taxol Aided by an Automated Synthesizer
Author(s) -
Doi Takayuki,
Fuse Shinichiro,
Miyamoto Shigeru,
Nakai Kazuoki,
Sasuga Daisuke,
Takahashi Takashi
Publication year - 2006
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200600156
Subject(s) - ring (chemistry) , key (lock) , chemistry , alkylation , stereochemistry , combinatorial chemistry , computer science , operating system , organic chemistry , catalysis
A 36‐step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave‐assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well‐known precursor of taxol.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom