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Countercation Transport Modeled by Porous Spherical Molybdenum Oxide Based Nanocapsules
Author(s) -
Rehder Dieter,
Haupt Erhard T. K.,
Bögge Hartmut,
Müller Achim
Publication year - 2006
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200600035
Subject(s) - nanocapsules , molybdenum , porosity , materials science , chemical engineering , molybdenum oxide , oxide , porous medium , nanotechnology , composite material , metallurgy , engineering , nanoparticle
Porous nanosized polyoxomolybdate capsule anions of composition [{Mo VI (Mo VI 5 O 21 )(H 2 O) 6 } 12 (linker) 30 ] n − , where (linker) 30 is {Mo V 2 O 4 (SO 4 )} 30 ( n =72) ( 1 a ) or {Mo V 2 O 4 (SO 4 )} 24 {Mo V 2 O 4 (CH 3 COO)} 6 ( n =64) ( 2 a ), model the (competitive) cellular transmembrane transport of Li + , Na + , K + , and Ca 2+ ions along ion channels. According to X‐ray crystallography and 7 Li and 23 Na NMR spectroscopy, Li + and Na + , the counterions for 1 a and 2 a , respectively, occupy internal sites of the capsule. This study of the counterion transport phenomenon shows that, while Li + ions can be replaced to a large extent by Na + and K + ions and completely by Ca 2+ ions added to a solution of 1 a , external Li + ions do not replace the incorporated Na + ions of 2 a in an analogous experiment. In this context, related properties of the capsules and especially of their flexible channels, in connection with the complex pathways of cation uptake, are discussed briefly. The relevance of these investigations for lithium‐based therapies is also addressed.