Premium
Microwave‐Assisted Heterogeneous Cross‐Coupling Reactions Catalyzed by Nickel‐in‐Charcoal (Ni/C)
Author(s) -
Lipshutz Bruce H.,
Frieman Bryan A.,
Lee ChingTien,
Lower Asher,
Nihan Danielle M.,
Taft Benjamin R.
Publication year - 2006
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200600031
Subject(s) - negishi coupling , nickel , catalysis , charcoal , microwave , aryl , chemistry , adsorption , activated charcoal , carbon fibers , vinyl chloride , activated carbon , coupling reaction , chemical engineering , polymer chemistry , inorganic chemistry , organic chemistry , materials science , composite material , physics , alkyl , polymer , quantum mechanics , composite number , engineering , copolymer
A study involving the relatively rare combination of heterogeneous catalysis conducted under microwave conditions is presented. Carbon–carbon bond formation, including Negishi and Suzuki couplings, can be quickly effected with aryl chloride partners by using a base metal (nickel) adsorbed in the pores of activated charcoal. Aminations were also studied, along with cross‐couplings of vinyl alanes with benzylic chlorides as a means to stereodefined allylated aromatics. Reaction times for all these processes are typically reduced from several hours to minutes in a microwave reactor.