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Diagnostic Assessment Strategies and Disease Subsets in Giant Cell Arteritis: Data From an International Observational Cohort
Author(s) -
Gribbons K. Bates,
Ponte Cristina,
Craven Anthea,
Robson Joanna C.,
Suppiah Ravi,
Luqmani Raashid,
Watts Richard,
Merkel Peter A.,
Grayson Peter C.
Publication year - 2020
Publication title -
arthritis and rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.106
H-Index - 314
eISSN - 2326-5205
pISSN - 2326-5191
DOI - 10.1002/art.41165
Subject(s) - abnormality , medicine , giant cell arteritis , neuroradiology , cohort , cardiology , arteritis , radiology , vasculitis , disease , neurology , psychiatry
Objective Diagnostic assessment in giant cell arteritis ( GCA ) is rapidly changing as vascular imaging becomes more available. This study was undertaken to determine if clinical GCA subsets have distinct profiles or reflect differential diagnostic assessments. Methods Patients were recruited from an international cohort and divided into 4 subsets based on a temporal artery ( TA ) abnormality (positive TA biopsy [ TAB ] or halo sign on TA ultrasound [ TA ‐ US ]) and/or evidence of large vessel ( LV ) involvement on imaging: 1) both TA abnormality and LV involvement ( TA +/ LV + GCA ); 2) TA abnormality without LV involvement ( TA +/ LV − GCA ); 3) LV involvement without TA abnormality ( TA −/ LV + GCA ); and 4) clinically diagnosed GCA without LV involvement or TA abnormality ( TA −/ LV − GCA ). Results Nine hundred forty‐one patients with GCA were recruited from 72 international study sites. Most patients received multiple forms of diagnostic assessment, including TAB (n = 705 [75%]), TA ‐ US (n = 328 [35%]), and LV imaging (n = 534 [57%]). Assessment using TAB , TA ‐ US , and LV imaging confirmed the diagnosis of GCA in 66%, 79%, and 40% of cases, respectively. GCA subsets had distinct profiles independent of diagnostic assessment strategies. TA +/ LV − were the most common subset (51%), with a high burden of cranial ischemia. Those in the TA −/ LV − subset (26%) had a high prevalence of cranial ischemia and musculoskeletal symptoms. Patients in the TA −/ LV + subset (12%) had prevalent upper extremity vascular abnormalities and a low prevalence of vision loss, and those in the TA +/ LV + subset (11%) were older and had a high prevalence of cranial ischemia, constitutional symptoms, and elevated acute‐phase reactant levels. Conclusion Vascular imaging is increasingly incorporated into the diagnostic assessment of GCA and identifies clinical subsets of patients based on involvement of temporal and extracranial arteries.