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Review: The Tumor‐Like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine
Author(s) -
You Sungyong,
Koh Jung Hee,
Leng Lin,
Kim WanUk,
Bucala Richard
Publication year - 2018
Publication title -
arthritis and rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.106
H-Index - 314
eISSN - 2326-5205
pISSN - 2326-5191
DOI - 10.1002/art.40406
Subject(s) - rheumatoid arthritis , pannus , phenotype , medicine , epigenomics , precision medicine , transcriptome , autoimmune disease , disease , bioinformatics , pathology , cancer research , immunology , biology , gene , gene expression , dna methylation , genetics
Rheumatoid arthritis ( RA ) is a systemic autoimmune disease characterized by destructive hyperplasia of the synovium. Fibroblast‐like synoviocytes ( FLS ) are a major component of synovial pannus and actively participate in the pathologic progression of RA . How rheumatoid FLS acquire and sustain such a uniquely aggressive phenotype remains poorly understood. We describe the current state of knowledge of the molecular alterations in rheumatoid FLS at the genomic, epigenomic, transcriptomic, proteomic, and metabolomic levels, which offers a means to reconstruct the pathways leading to rheumatoid pannus. Such data provide new pathologic insight and suggest means to more sensitively assess disease activity and response to therapy, as well as support new avenues for therapeutic development.