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Regional Differences Between Perisynovial and Infrapatellar Adipose Tissue Depots and Their Response to Class II and III Obesity in Patients With Osteoarthritis: Comment on the Article by Harasymowicz et al
Author(s) -
Macchi Veronica,
Porzionato Andrea,
Rossato Marco,
De Caro Raffaele
Publication year - 2018
Publication title -
arthritis and rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.106
H-Index - 314
eISSN - 2326-5205
pISSN - 2326-5191
DOI - 10.1002/art.40241
Subject(s) - osteoarthritis , infrapatellar fat pad , adipose tissue , obesity , medicine , class (philosophy) , physical therapy , pathology , alternative medicine , philosophy , epistemology
Harasymowicz et al (1) are to be congratulated for their recent article regarding the presence of regional differences between perisynovial and infrapatellar adipose tissue depots and their response to Class II and III Obesity in Patients with osteoarthritis (OA). The Authors report that the infrapatellar fat pad (IFP) and synovium adipose tissue depots differ significantly and are influenced by the patient's BMI. In particular, obese patients' adipocytes from IPF are significantly larger while in the synovium, there was marked fibrosis, macrophage infiltration and higher TLR4 expression identified in comparison to lean subjects. We would like to share our anatomical experience on adipocytes of IPF (2). This article is protected by copyright. All rights reserved