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Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project
Author(s) -
Qin Jin,
Barbour Kamil E.,
Murphy Louise B.,
Nelson Amanda E.,
Schwartz Todd A.,
Helmick Charles G.,
Allen Kelli D.,
Renner Jordan B.,
Baker Nancy A.,
Jordan Joanne M.
Publication year - 2017
Publication title -
arthritis and rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.106
H-Index - 314
eISSN - 2326-5205
pISSN - 2326-5191
DOI - 10.1002/art.40097
Subject(s) - medicine , osteoarthritis , confidence interval , population , lifetime risk , physical therapy , cohort , rotterdam study , cohort study , prospective cohort study , relative risk , demography , environmental health , alternative medicine , pathology , sociology
Objective Symptomatic hand osteoarthritis (OA) is a common condition that affects hand strength and function, and causes disability in activities of daily living. Prior studies have estimated that the lifetime risk of symptomatic knee OA is 45% and that of hip OA is 25%. The objective of the present study was to estimate the overall lifetime risk of symptomatic hand OA, and the stratified lifetime risk according to potential risk factors. Methods Data were obtained from 2,218 adult subjects (ages ≥45 years) in the Johnston County Osteoarthritis Project, a population‐based prospective cohort study among residents of Johnston County, North Carolina. Data for the present study were collected from 2 of the follow‐up cycles (1999–2004 and 2005–2010). Symptomatic hand OA was defined as the presence of both self‐reported symptoms and radiographic OA in the same hand. Lifetime risk, defined as the proportion of the population who will develop symptomatic hand OA in at least 1 hand by age 85 years, was estimated from models using generalized estimating equations. Results Overall, the lifetime risk of symptomatic hand OA was 39.8% (95% confidence interval [95% CI] 34.4–45.3%). In this population, nearly 1 in 2 women (47.2%, 95% CI 40.6–53.9%) had an estimated lifetime risk of developing symptomatic hand OA by age 85 years, compared with 1 in 4 men (24.6%, 95% CI 19.5–30.5%). Race‐specific symptomatic hand OA risk estimates were 41.4% (95% CI 35.5–47.6%) among whites and 29.2% (95% CI 20.5–39.7%) among African Americans. The lifetime risk of symptomatic hand OA among individuals with obesity (47.1%, 95% CI 37.8–56.7%) was 11 percentage points higher than that in individuals without obesity (36.1%, 95% CI 29.7–42.9%). Conclusion These findings demonstrate the substantial burden of symptomatic hand OA overall and in sociodemographic and clinical subgroups. Increased use of public health and clinical interventions is needed to address its impact.