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Review: Metabolic Regulation of Inflammation in Osteoarthritis
Author(s) -
Berenbaum Francis,
Griffin Timothy M.,
LiuBryan Ru
Publication year - 2017
Publication title -
arthritis and rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.106
H-Index - 314
eISSN - 2326-5205
pISSN - 2326-5191
DOI - 10.1002/art.39842
Subject(s) - osteoarthritis , articular cartilage , inflammation , cartilage , medicine , joint (building) , process (computing) , anatomy , pathology , computer science , engineering , alternative medicine , architectural engineering , operating system
International audienceOsteoarthritis (OA) has long been considered the unique consequence of a tear and wearprocess leading to cartilage degradation. Indeed, it is true that an excessive mechanical stress on any joint leads to cartilage loss, with the production of osteophytes being considered a reactive process of the bone to protect and stabilize the altered joint (1). This initial paradigm has been slowly but deeply modified in the past 20 years due to critical discoveries (2)