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Reduction of Cerebral and Corpus Callosum Volumes in Childhood‐Onset Systemic Lupus Erythematosus: A Volumetric Magnetic Resonance Imaging Analysis
Author(s) -
Tamires Lapa Aline,
Postal Mariana,
Angélica Sinicato Nailú,
Geraldo Ferreira Weslley,
Siqueira Bellini Bruna,
Teixeira Fernandes Paula,
Rittner Leticia,
Marini Roberto,
Cendes Fernando,
Appenzeller Simone
Publication year - 2016
Publication title -
arthritis and rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.106
H-Index - 314
eISSN - 2326-5205
pISSN - 2326-5191
DOI - 10.1002/art.39680
Subject(s) - medicine , corpus callosum , atrophy , magnetic resonance imaging , cerebral atrophy , cardiology , pathology , radiology
Objective There have been few studies in which the prevalence of cerebral atrophy in childhood‐onset systemic lupus erythematosus (SLE) was evaluated using magnetic resonance imaging (MRI) volumetric measurements. This study was undertaken to determine the prevalence of cerebral and corpus callosum atrophy in childhood‐onset SLE and to determine the possible relationships between atrophy and clinical, laboratory, and treatment features of the disease. Methods We included 76 patients with childhood‐onset SLE (69 female and 7 male; median age 16 years) and 66 age‐ and sex‐matched healthy controls. Neurologic manifestations were analyzed according to the American College of Rheumatology (ACR) criteria. These SLE patients were further assessed for clinical and laboratory manifestations of SLE, disease activity (using the SLE Disease Activity Index), damage (using the Systemic Lupus International Collaborating Clinics/ACR Damage Index), and current and cumulative drug exposures. Scans were performed with a Philips 3.0T MRI scanner using a standardized protocol. Results Childhood‐onset SLE patients had significantly smaller cerebral and corpus callosum volumes than controls (median cerebral volume 1,067.9 cm 3 versus 1,172.7 cm 3 and median corpus callosum volume 11.6 cm 3 versus 13.7 cm 3 ; P < 0.001). The presence of structural abnormalities was observed in 42 patients (55.3%) with childhood‐onset SLE. The presence of cerebral atrophy was associated with anticardiolipin antibodies (aCL) ( P = 0.02), anti–double‐stranded DNA ( P = 0.02), and cumulative corticosteroid dose ( P = 0.04). The presence of corpus callosum atrophy was associated with low complement level ( P = 0.006) and acute confusional state ( P = 0.01). Serum levels of S100B or high molecular weight neurofilament and the presence of anti–ribosomal P were not associated with atrophy. Conclusion Structural brain abnormalities were observed in 55.3% of the patients and were associated with neuropsychiatric manifestations, aCL, and corticosteroid use. To determine permanent neurologic damage, longitudinal studies must be conducted in these patients.