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Population‐Based Incidence and Prevalence of Systemic Lupus Erythematosus: The Michigan Lupus Epidemiology and Surveillance Program
Author(s) -
Somers Emily C.,
Marder Wendy,
Cagnoli Patricia,
Lewis Emily E.,
DeGuire Peter,
Gordon Caroline,
Helmick Charles G.,
Wang Lu,
Wing Jeffrey J.,
Dhar J. Patricia,
Leisen James,
Shaltis Diane,
McCune W. Joseph
Publication year - 2014
Publication title -
arthritis and rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.106
H-Index - 314
eISSN - 2326-5205
pISSN - 2326-5191
DOI - 10.1002/art.38238
Subject(s) - medicine , systemic lupus erythematosus , incidence (geometry) , epidemiology , population , confidence interval , rheumatology , disease , rochester epidemiology project , demography , pediatrics , population based study , environmental health , physics , sociology , optics
Objective To estimate the incidence and prevalence of systemic lupus erythematosus (SLE) in a sociodemographically diverse southeastern Michigan source population of 2.4 million people. Methods SLE cases fulfilling the American College of Rheumatology classification criteria (primary case definition) or meeting rheumatologist‐judged SLE criteria (secondary definition) and residing in Wayne or Washtenaw Counties during 2002–2004 were included. Case finding was performed from 6 source types, including hospitals and private specialists. Age‐standardized rates were computed, and capture–recapture was performed to estimate underascertainment of cases. Results The overall age‐adjusted incidence and prevalence (ACR definition) per 100,000 persons were 5.5 (95% confidence interval [95% CI] 5.0–6.1) and 72.8 (95% CI 70.8–74.8). Among females, the incidence was 9.3 per 100,000 persons and the prevalence was 128.7 per 100,000 persons. Only 7 cases were estimated to have been missed by capture–recapture, adjustment for which did not materially affect the rates. SLE prevalence was 2.3‐fold higher in black persons than in white persons, and 10‐fold higher in females than in males. Among incident cases, the mean ± SD age at diagnosis was 39.3 ± 16.6 years. Black SLE patients had a higher proportion of renal disease and end‐stage renal disease (ESRD) (40.5% and 15.3%, respectively) as compared to white SLE patients (18.8% and 4.5%, respectively). Black patients with renal disease were diagnosed as having SLE at younger age than white patients with renal disease (mean ± SD 34.4 ± 14.9 years versus 41.9 ± 21.3 years; P = 0.05). Conclusion SLE prevalence was higher than has been described in most other population‐based studies and reached 1 in 537 among black female persons. There were substantial racial disparities in the burden of SLE, with black patients experiencing earlier age at diagnosis, >2‐fold increases in SLE incidence and prevalence, and increased proportions of renal disease and progression to ESRD as compared to white patients.