Open AccessImpact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian–European populations
Author(s) -
Sánchez Elena,
Rasmussen Astrid,
Riba Laura,
AcevedoVasquez Eduardo,
Kelly Jennifer A.,
Langefeld Carl D.,
Williams Adrianne H.,
Ziegler Julie T.,
Comeau Mary E.,
Marion Miranda C.,
GarcíaDe La Torre Ignacio,
MaradiagaCeceña Marco A.,
Cardiel Mario H.,
EsquivelValerio Jorge A.,
RodriguezAmado Jacqueline,
Moctezuma José Francisco,
Miranda Pedro,
Perandones Carlos E.,
Castel Cecilia,
Laborde Hugo A.,
Alba Paula,
Musuruana Jorge L.,
Goecke I. Annelise,
Anaya JuanManuel,
Kaufman Kenneth M.,
Adler Adam,
Glenn Stuart B.,
Brown Elizabeth E.,
Alarcón Graciela S.,
Kimberly Robert P.,
Edberg Jeffrey C.,
Vilá Luis M.,
Criswell Lindsey A.,
Gilkeson Gary S.,
Niewold Timothy B.,
Martín Javier,
Vyse Timothy J.,
Boackle Susan A.,
RamseyGoldman Rosalind,
Scofield R. Hal,
Petri Michelle,
Merrill Joan T.,
Reveille John D.,
Tsao Betty P.,
Orozco Lorena,
Baca Vicente,
Moser Kathy L.,
Gaffney Patrick M.,
James Judith A.,
Harley John B.,
TusiéLuna Teresa,
PonsEstel Bernardo A.,
Jacob Chaim O.,
AlarcónRiquelme Marta E.
Publication year - 2012
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.34650
Subject(s) - genetic genealogy , medicine , ancestry informative marker , odds ratio , serositis , cohort , malar rash , confidence interval , demography , arthritis , immunology , population , genotype , allele frequency , biology , genetics , anti nuclear antibody , environmental health , sociology , gene , antibody , autoantibody
Objective American Indian–Europeans, Asians, and African Americans have an excess morbidity from systemic lupus erythematosus (SLE) and a higher prevalence of lupus nephritis than do Caucasians. The aim of this study was to analyze the relationship between genetic ancestry and sociodemographic characteristics and clinical features in a large cohort of American Indian–European SLE patients. Methods A total of 2,116 SLE patients of American Indian–European origin and 4,001 SLE patients of European descent for whom we had clinical data were included in the study. Genotyping of 253 continental ancestry‐informative markers was performed on the Illumina platform. Structure and Admixture software were used to determine genetic ancestry proportions of each individual. Logistic regression was used to test the association between genetic ancestry and sociodemographic and clinical characteristics. Odds ratios (ORs) were calculated with 95% confidence intervals (95% CIs). Results The average American Indian genetic ancestry of 2,116 SLE patients was 40.7%. American Indian genetic ancestry conferred increased risks of renal involvement ( P < 0.0001, OR 3.50 [95% CI 2.63– 4.63]) and early age at onset ( P < 0.0001). American Indian ancestry protected against photosensitivity ( P < 0.0001, OR 0.58 [95% CI 0.44–0.76]), oral ulcers ( P < 0.0001, OR 0.55 [95% CI 0.42–0.72]), and serositis ( P < 0.0001, OR 0.56 [95% CI 0.41–0.75]) after adjustment for age, sex, and age at onset. However, age and sex had stronger effects than genetic ancestry on malar rash, discoid rash, arthritis, and neurologic involvement. Conclusion In general, American Indian genetic ancestry correlates with lower sociodemographic status and increases the risk of developing renal involvement and SLE at an earlier age.