Open AccessIndependent association of joint space narrowing and osteophyte formation at the knee with health‐related quality of life in Japan: A cross‐sectional study
Author(s) -
Muraki Shigeyuki,
Oka Hiroyuki,
Akune Toru,
EnYo Yoshio,
Yoshida Munehito,
Suzuki Takao,
Yoshida Hideyo,
Ishibashi Hideaki,
Tokimura Fumiaki,
Yamamoto Seizo,
Nakamura Kozo,
Kawaguchi Hiroshi,
Yoshimura Noriko
Publication year - 2011
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.30641
Subject(s) - womac , osteoarthritis , medicine , cross sectional study , quality of life (healthcare) , body mass index , physical therapy , population , knee pain , knee joint , cohort , surgery , pathology , environmental health , alternative medicine , nursing
Objective To clarify the individual associations of joint space narrowing (JSN) and osteophytosis at the knee with quality of life (QOL) in Japanese men and women using a large‐scale population‐based cohort from the Research on Osteoarthritis Against Disability (ROAD) study. Methods The associations of minimum joint space width (JSW) and osteophyte area in the medial compartment of the knee with QOL parameters, such as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), were examined. Minimum JSW and osteophyte area in the medial compartment of the knee were measured using a computer‐aided system for the diagnosis of knee osteoarthritis. Results Of the 3,040 participants in the ROAD study, the present study included 2,039 participants age 40 years or older who completed the questionnaires (741 men and 1,298 women with a mean ± SD age of 68.6 ± 10.9 years). Multiple regression analysis after adjustment for age and body mass index showed that minimum JSW was significantly associated with scores on the pain domains of the WOMAC in men and women, while osteophyte area was significantly associated with scores on the physical function domains of the WOMAC in men and women. Conclusion The findings of this cross‐sectional study using a large‐scale population from the ROAD study indicate that JSN and osteophytosis are independently associated with QOL.