A meta‐analysis of the effect size of rheumatoid arthritis on left ventricular mass: Comment on the article by Rudominer et al

tive pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 2001;194:823–32. 3. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003;3:199–210. 4. Bayry J, Triebel F, Kaveri SV, Tough DF. Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4 CD25 regulatory T cells. J Immunol 2007;178:4184–93. 5. Houot R, Perrot I, Garcia E, Durand I, Lebecque S. Human CD4 CD25high regulatory T cells modulate myeloid but not plasmacytoid dendritic cells activation. J Immunol 2006;176:5293–8. 6. Onishi Y, Fehervari Z, Yamaguchi T, Sakaguchi S. Foxp3 natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci U S A 2008;105:10113–8. 7. Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, et al. CTLA-4 control over Foxp3 regulatory T cell function. Science 2008;322:271–5. 8. Tang Q, Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, Bluestone JA. Distinct roles of CTLA-4 and TGFin CD4 CD25 regulatory T cell function. Eur J Immunol 2004;34:2996–3005. 9. Brunner-Weinzierl MC, Hoff H, Burmester GR. Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases. Arthritis Res Ther 2004;6:45–54. 10. Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, et al. CD4 regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med 2009;206:421–34. 11. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995;3:541–7. 12. Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995;270:985–8. 13. Verhagen J, Gabrysova L, Minaee S, Sabatos CA, Anderson G, Sharpe AH, et al. Enhanced selection of FoxP3 T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease. Proc Natl Acad Sci U S A 2009;106:3306–11.