Open AccessThe PRL –1149 G/T polymorphism and rheumatoid arthritis susceptibility
Author(s) -
Lee Yvonne C.,
Raychaudhuri Soumya,
Cui Jing,
de Vivo Immaculata,
Ding Bo,
Alfredsson Lars,
Padyukov Leonid,
Costenbader Karen H.,
Seielstad Mark,
Graham Robert R.,
Klareskog Lars,
Gregersen Peter K.,
Plenge Robert M.,
Karlson Elizabeth W.
Publication year - 2009
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.24468
Subject(s) - rheumatoid arthritis , odds ratio , genotyping , medicine , allele , confidence interval , polymorphism (computer science) , minor allele frequency , genetic predisposition , immunology , genotype , allele frequency , disease , biology , genetics , gene
Objective Previous studies have demonstrated that the PRL −1149 T (minor) allele decreases prolactin expression and may be associated with autoimmune disease. The aim of this study was to determine the role of the PRL −1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility. Methods We examined the association between PRL −1149 G/T and RA risk in 4 separate study populations, consisting of a total of 3,405 RA cases and 4,111 controls of self‐reported white European ancestry. Samples were genotyped using 1 of 3 genotyping platforms, and strict quality control metrics were applied. We tested for association using a 2‐tailed Cochran‐Mantel‐Haenszel additive, fixed‐effects model. Results In the individual populations, odds ratios (ORs) for an association between PRL −1149 T and RA risk ranged from 0.80 to 0.97. In a joint meta‐analysis across all 4 populations, the OR for an association between PRL −1149 T and RA risk was 0.90 (95% confidence interval 0.84–0.96, P = 0.001). Conclusion Our findings indicate a possible association between the PRL −1149 T allele and decreased RA risk. The effect size is small but similar to ORs for other genetic polymorphisms associated with complex traits, including RA.