Open AccessSuccessful treatment of resistant pseudogout with anakinra
Author(s) -
McGonagle Dennis,
Tan Ai Lyn,
Madden Julie,
Emery Paul,
McDermott Michael F.
Publication year - 2008
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.23119
Subject(s) - anakinra , pseudogout , medicine , allopurinol , inflammation , chondrocalcinosis , gastroenterology , arthritis , pathology , disease , alternative medicine , osteoarthritis
We describe herein the case of a 63‐year‐old man with pseudogout affecting multiple joints that was resistant to treatment with allopurinol, steroids, and antiinflammatory drugs. Based on recent data on the molecular mechanism of pseudogout that demonstrated overproduction of interleukin‐1 (IL‐1), we treated the patient with anakinra, an IL‐1 receptor antagonist. The patient responded to treatment with anakinra within 2 weeks, with resolution of the signs and symptoms of pseudogout and normalization of levels of inflammation markers.