Open AccessAssociation of a CD24 gene polymorphism with susceptibility to systemic lupus erythematosus
Author(s) -
Sánchez Elena,
Abelson AnnaKarin,
Sabio Jose M.,
GonzálezGay Miguel A.,
OrtegoCenteno Norberto,
JiménezAlonso Juan,
de Ramón Enrique,
SánchezRomán Julio,
LópezNevot Miguel A.,
Gunnarsson Iva,
Svenungsson Elisabet,
Sturfelt Gunnar,
Truedsson Lennart,
Jönsen Andreas,
GonzálezEscribano Maria Francisca,
Witte Torsten,
AlarcónRiquelme Marta E.,
Martín Javier
Publication year - 2007
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.22871
Subject(s) - medicine , odds ratio , genotype , cohort , gastroenterology , allele , population , immunology , confidence interval , allele frequency , case control study , genetics , biology , gene , environmental health
Objective To determine the potential role of the CD24 A57V gene polymorphism in systemic lupus erythematosus (SLE). Methods We studied 3 cohorts of Caucasian patients and controls. The Spanish cohort included 696 SLE patients and 539 controls, the German cohort included 257 SLE patients and 317 controls, and the Swedish cohort included 310 SLE patients and 247 controls. The CD24 A57V polymorphism was genotyped by polymerase chain reaction, using a predeveloped TaqMan allele discrimination assay. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results In the Spanish cohort there was a statistically significant difference in the distribution of the CD24 V allele between SLE patients and controls (OR 3.6 [95% CI 2.13–6.16], P < 0.0001). In addition, frequency of the CD24 V/V genotype was increased in SLE patients compared with controls (OR 3.7 [95% CI 2.16–6.34], P < 0.00001). We sought to replicate this association with SLE in a German population and a Swedish population. A similar trend was found in the German group. The CD24 V/V genotype and the CD24 V allele were more frequent in SLE patients than in controls, although this difference was not statistically significant. No differences were observed in the Swedish group. A meta‐analysis of the Spanish and German cohorts demonstrated that the CD24 V allele has a risk effect in SLE patients (pooled OR 1.25 [95% CI 1.08–1.46], P = 0.003). In addition, homozygosity for the CD24 V risk allele significantly increased the effect (pooled OR 2.19 [95% CI 1.50–3.22], P = 0.00007). Conclusion These findings suggest that the CD24 A57V polymorphism plays a role in susceptibility to SLE in a Spanish population.