Open AccessSuccessful treatment of SAPHO syndrome with zoledronic acid
Author(s) -
Kopterides Petros,
Pikazis Dimitrios,
Koufos Christos
Publication year - 2004
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.20464
Subject(s) - sapho syndrome , pustulosis , medicine , hyperostosis , acne , osteitis , zoledronic acid , dermatology , synovitis , nonsteroidal , surgery , osteomyelitis , arthritis
The SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a chronic, relapsing, inflammatory condition with skin and osteoarticular manifestations. Its etiology remains unclear, and various treatment regimens with steroids and nonsteroidal antiinflammatory drugs frequently fail to control the disease, while exposing patients to the side effects of these drugs. Because the SAPHO syndrome manifests as a destructive inflammatory bone disease, use of bisphosphonates that possess antiosteoclastic and probably antiinflammatory properties has been suggested to be helpful. To our knowledge, this is the first reported case of successful treatment with zoledronic acid of SAPHO syndrome that was resistant to conventional treatment.