Open AccessThe N of 1 trials design in the rheumatic diseases
Author(s) -
Giannini Edward H.
Publication year - 1988
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1790010207
Subject(s) - medicine , modality (human–computer interaction) , medical physics , clinical study design , clinical trial , variety (cybernetics) , alternative medicine , subject (documents) , computer science , intensive care medicine , physical therapy , pathology , artificial intelligence , library science
Recently the N of 1, or single case experimental trial design, has increased in popularity among physicians and therapists interested in assessing the usefulness of a therapeutic modality within a single subject [1, 2]. The techniques are not considered new; single case experimental designs have found acceptance and widespread use for many years in the behavioral sciences [3]. Additionally, experimental physiology and medicine have employed these methods extensively over the last few decades, although there is a relative paucity of articles in the clinical literature that report the results of N of 1 trials. There is a variety of design options possible for N of 1 studies, and the interested reader is referred to Reference 3 for a more comprehensive review of the topic. This paper will review a few of the major design options, with particular attention given to the alternating treatment design (ATD). The advantages and drawbacks of the N of 1 technique, with specific reference to the field of rheumatology, will be the main emphasis.