Open AccessMannose‐binding protein genetic polymorphisms in black patients with systemic lupus erythematosus
Author(s) -
Sullivan Kathleen E.,
Wooten Candra,
Goldman Daniel,
Petri Michelle
Publication year - 1996
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780391214
Subject(s) - haplotype , mannan binding lectin , immunology , allele , dysfunctional family , medicine , lupus erythematosus , polymerase chain reaction , population , allele frequency , biology , gene , genetics , antibody , lectin , clinical psychology , environmental health
Objective . To determine whether dysfunctional or deficient mannose‐binding protein (MBP) variants are found with increased frequency in black patients with systemic lupus erythematosus (SLE) compared with controls. Methods . Allele‐specific polymerase chain reaction amplification of 4 different polymorphic sites was performed on samples from 92 black SLE patients and 86 geographically matched black controls. Results . Two structural polymorphisms of MBP, associated with low serum levels of MBP, were found with significantly increased frequency in the SLE patient population compared with controls. In contrast, a promoter haplotype associated with particularly high serum levels of MBP was negatively associated with SLE. Conclusion . Deficiencies of MBP predispose individuals to SLE.