Open AccessAbnormal vitamin b 6 status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation
Author(s) -
Roubenoff Ronenn,
Roubenoff Rebecca A.,
Selhub Jacob,
Nadeau Marie R.,
Can Joseph G.,
Freeman Lisa M.,
Dinarello Charles A.,
Rosenberg Irwin H.
Publication year - 1995
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780380116
Subject(s) - cachexia , inflammation , tumor necrosis factor alpha , medicine , tumor necrosis factor α , rheumatoid arthritis , vitamin d and neurology , necrosis , immunology , gastroenterology , cancer
Abstract Objective. To compare vitamin B 6 levels in rheumatoid arthritis (RA) patients and healthy control subjects. Methods. We measured levels of vitamin B 6 in 23 adults with well‐controlled RA, and in 23 healthy control subjects matched for age, sex, race, and weight. Results. Although plasma folate and vitamin B 12 concentrations and erythrocyte B 6 activity coefficients were similar in the patients and controls, plasma levels of pyridoxal‐5′‐phosphate (PLP) were lower in the RA patient group (mean ± SD 46.1 ± 48.1 versus 69.3 ± 58.4 nmoles/liter; P ≤ 0.004). In multivariate analyses, PLP was inversely associated with tumor necrosis factor α (TNFα) production by peripheral blood mononuclear cells (PBMC) ( P < 0.001), after adjustment for age, pain score, erythrocyte sedimentation rate, and use of nonsteroidal antiinflammatory drugs. Conclusion. PLP levels are reduced in patients with RA. This reduction is associated with TNFα production by PBMC.