Open AccessOutcome of polyarteritis nodosa and churg‐strauss syndrome
Author(s) -
AbuShakra Mahmoud,
Smythe Hugh,
Lewtas Jody,
Badley Elizabeth,
Weber Deborah,
Keystone Edward
Publication year - 1994
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780371214
Subject(s) - medicine , polyarteritis nodosa , churg strauss syndrome , vasculitis , mortality rate , single center , retrospective cohort study , surgery , disease
Objective . To compare outcome in patients with polyarteritis nodosa (PAN) and patients with Churg‐Strauss syndrome (CSS) followed up at a single center. Methods . A retrospective data review of 13 patients with PAN and 12 patients with CSS who were followed up at a vasculitis clinic. Outcome measures included a global damage index, disability and pain dimensions of the Health Assessment Questionnaire, and mortality rate. Results . Compared with patients with CSS, patients with PAN had a significantly higher mean damage index score (5.15 versus 2.42; P = 0.011), a higher disability score (1.09 versus 0.16; P = 0.007), and a higher pain score (1.04 versus 0.01; P = 0.017). Patients with PAN had more relapses (relative risk = 5.07; P < 0.000) and a higher mortality rate (31%) compared with patients with CSS (8%). Conclusion . PAN and CSS differ in their morbidity and mortality; therefore, they should be considered as distinct clinical entities.