Combined treatment with terbutaline and aminophylline inhibits experimental amyloidosis in mice | Zendy

Brandwein Sydney R. | Zendy; Sipe Jean D. | Zendy; Cohen Alan S. | Zendy

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Combined treatment with terbutaline and aminophylline inhibits experimental amyloidosis in mice

Author(s) -

Brandwein Sydney R.,

Sipe Jean D.,

Cohen Alan S.

Publication year - 1994

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780371208

Subject(s) - aminophylline , terbutaline , amyloidosis , phosphodiesterase inhibitor , medicine , colchicine , theophylline , cyclic adenosine monophosphate , endocrinology , pharmacology , stimulation , salbutamol , aa amyloidosis , amyloid (mycology) , chemistry , pathology , receptor , asthma , familial mediterranean fever , disease

Objective . To investigate the effects of drugs known to elevate adenosine 3':5'‐cyclic monophosphate (cAMP) on experimental amyloidosis. Methods . A β 2 ‐agonist, terbutaline, and a phosphodiesterase inhibitor, aminophylline, were administered in combination in a mouse model of amyloidosis induced by inflammatory stimulation with silver nitrate. Amyloidosis was quantitated by radioimmunoassay for splenic amyloid A (AA) protein. Results . At the doses selected, aminophylline/ terbutaline inhibited splenic amyloid deposition more potently than did colchicine, a known inhibitor of amyloidosis. Conclusion . Drugs known to elevate cAMP inhibit experimental mouse AA amyloidosis.

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