Concentration of autoantibodies to native 60‐kd ro/ss‐a and denatured 52‐kd ro/ss‐a in eluates from the heart of a child who died with congenital complete heart block | Zendy

Reichlin Morris | Zendy; Brucato Antonio | Zendy; Frank Mark B. | Zendy; Maddison Peter J. | Zendy; Mccubbin Victoria R. | Zendy; WolfsonReichlin Marianne | Zendy; Lee Lela A. | Zendy

Open Access

Concentration of autoantibodies to native 60‐kd ro/ss‐a and denatured 52‐kd ro/ss‐a in eluates from the heart of a child who died with congenital complete heart block

Author(s) -

Reichlin Morris,

Brucato Antonio,

Frank Mark B.,

Maddison Peter J.,

Mccubbin Victoria R.,

WolfsonReichlin Marianne,

Lee Lela A.

Publication year - 1994

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780371120

Subject(s) - titer , antibody , serology , medicine , autoantibody , heart block , microbiology and biotechnology , biology , immunology , electrocardiography

Objective. To determine the serologic specificity of acid eluates from tissues of a child who died with congenital complete heart block (CCHB). Methods. Tissues were extracted, acid eluted, and the IgG and antibody titers determined on the eluates by enzyme‐linked immunosorbent assay. Results. Antibodies to native 60‐kd and denatured 52‐kd Ro/SS‐A were found to be enriched only in the heart eluate, and not in the eluates from brain, kidney, and skin. Conclusion. These findings indicate a major role for anti–native 60‐kd Ro/SS‐A in the immunopathogenesis of CCHB.

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