Open AccessFamilial polyarteritis nodosa
Author(s) -
Mason Justin C.,
Cowie Martin R.,
Davies Kevin A.,
Schofield John B.,
Cambridge Jo,
Jackson James,
So Alex,
Allard Simon A.,
Walport Mark J.
Publication year - 1994
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780370821
Subject(s) - polyarteritis nodosa , autoimmunity , haplotype , family history , human leukocyte antigen , medicine , connective tissue disorder , dermatology , immunology , pathology , genetics , biology , vasculitis , gene , allele , antigen , disease , antibody
Familial polyarteritis nodosa (PAN) is rare. We describe here two siblings who developed PAN 8 years apart. HLA typing showed that the affected family members shared a common haplotype with their unaffected mother. Further study of the family history suggested the possibility of an inherited disorder of connective tissue predisposing to autoimmunity and aneurysm formation.