Familial polyarteritis nodosa | Zendy

Mason Justin C. | Zendy; Cowie Martin R. | Zendy; Davies Kevin A. | Zendy; Schofield John B. | Zendy; Cambridge Jo | Zendy; Jackson James | Zendy; So Alex | Zendy; Allard Simon A. | Zendy; Walport Mark J. | Zendy

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Familial polyarteritis nodosa

Author(s) -

Mason Justin C.,

Cowie Martin R.,

Davies Kevin A.,

Schofield John B.,

Cambridge Jo,

Jackson James,

So Alex,

Allard Simon A.,

Walport Mark J.

Publication year - 1994

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780370821

Subject(s) - polyarteritis nodosa , autoimmunity , haplotype , family history , human leukocyte antigen , medicine , connective tissue disorder , dermatology , immunology , pathology , genetics , biology , vasculitis , gene , allele , antigen , disease , antibody

Familial polyarteritis nodosa (PAN) is rare. We describe here two siblings who developed PAN 8 years apart. HLA typing showed that the affected family members shared a common haplotype with their unaffected mother. Further study of the family history suggested the possibility of an inherited disorder of connective tissue predisposing to autoimmunity and aneurysm formation.

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