Open AccessRacial differences in the distribution of systemic sclerosis–related serum antinuclear antibodies
Author(s) -
Kuwana Masataka,
Okano Yutaka,
Kaburaki Junichi,
Tojo Takeshi,
Medsger Thomas A.
Publication year - 1994
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780370619
Subject(s) - anti nuclear antibody , antibody , indirect immunofluorescence , medicine , immunofluorescence , ouchterlony double immunodiffusion , immunodiffusion , immunology , scleroderma (fungus) , autoantibody , connective tissue disease , autoimmune disease , antiserum , inoculation
Abstract Objective. To determine racial differences in the frequencies of systemic sclerosis (SSc)–related serum antinuclear antibodies (ANA).Methods. We tested serum samples from 275 Japanese, 416 North American Caucasian, and 24 North American black SSc patients for 8 SSc‐related serum ANA, using indirect immunofluorescence, double immunodiffusion, and radioimmunoprecipitation assays.Results. In comparing the 3 racial groups, we found that anti–U1 RNP, anti–RNA polymerase I, II, and III, and anti–U3 RNP antibodies were the most frequently detected antibodies in Japanese, Caucasian, and black patients, respectively. Anti–PM‐Scl antibody was found exclusively in Caucasians.Conclusion. The production of SSc‐related serum ANA is related to immunogenetic background.