Open AccessHLA and T cell receptor β‐chain DNA polymorphisms identify a distinct subset of patients with pauciarticular‐onset juvenile rheumatoid arthritis
Author(s) -
Charmley Patrick,
Nepom Barbara S.,
Concan Patrick
Publication year - 1994
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780370513
Subject(s) - haplotype , t cell receptor , juvenile rheumatoid arthritis , genotype , biology , pathogenesis , allele , immunology , gene , human leukocyte antigen , genetics , arthritis , t cell , immune system , antigen
Objective . To evaluate and extend upon a reported association of a T cell receptor (TCR) V β coding region polymorphism with pauciarticular‐onset juvenile rheumatoid arthritis (JRA). Methods . TCR V β 6.1 genotypes and haplotypes in JRA and control groups were determined by DNA amplification. Results . Haplotypes of the V β 6.1 gene which encode a nonfunctional form of V β 6.1 were significantly associated with pauciarticular JRA in patients possessing the HLA–DQA1*0101 allele ( P = 0.0073). Conclusion . A TCR V β gene segment in the vicinity of V β 6.1, possibly V β 6.1, is apparently involved in the pathogenesis of pauciarticular‐onset JRA in DQA1*0101‐positive individuals.