Open AccessAntihistone Antibodies in Systemic Sclerosis
Author(s) -
Sato Shinichi,
Ihn Hironobu,
Kikuchi Kanako,
Takehara Kazuhiko
Publication year - 1994
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780370313
Subject(s) - serology , medicine , scleroderma (fungus) , autoantibody , antibody , pulmonary fibrosis , immunology , antigen , connective tissue disease , systemic disease , immunopathology , fibrosis , pathology , autoimmune disease , inoculation
Abstract Objective . To determine the prevalence and clinical significance of antihistone antibodies (AHA) in systemic sclerosis (SSc). Methods . Serum samples from patients with limited cutaneous SSc (n = 44), diffuse cutaneous SSc (dcSSc; n = 48), and other SSc‐related disorders (n = 22) were examined by enzyme‐linked immunosorbent assay and immunoblotting for AHA. Results . AHA were demonstrated in 29% of the 92 SSc patients and in 44% of those with dcSSc. The presence of AHA correlated with severe pulmonary fibrosis in those with dcSSc. Immunoblotting revealed that the predominant antigen was histone H1. Conclusion . AHA might be a serologic indicator of the severity of pulmonary fibrosis in SSc.