Open AccessTransforming growth factor β exerts opposite effects from interleukin‐1β on cultured rabbit articular chondrocytes through reduction of interleukin‐1 receptor expression
Author(s) -
Réadini F.,
Mauviel A.,
Pronost S.,
Loyau G.,
Pujol J.P.
Publication year - 1993
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780360108
Subject(s) - transforming growth factor , collagenase , interleukin 1 receptor antagonist , receptor , interleukin , chemistry , receptor antagonist , endocrinology , medicine , interleukin 1 receptor , glycosaminoglycan , cytokine , microbiology and biotechnology , biology , antagonist , biochemistry , enzyme
Objective. The aim of the study was to determine whether transforming growth factor β (TGFβ) modulates the effects and the receptor expression of interleukin‐1 (IL‐1) in rabbit articular chondrocytes (RAC). Methods. Collagen, glycosaminoglycan, and collagenase production, together with 125 I‐labeled IL‐1 binding, were analyzed in RAC cultures. Results. TGFβ reduced both IL‐1 effects on matrix metabolism and IL‐1 receptor expression. Conclusion. TGF/3 acts as an antagonist of the effects of IL‐1 through down‐regulation of its receptor expression.