Open AccessMusculoskeletal manifestations in β 2 ‐microglobulin amyloidosis. Case discussion
Author(s) -
Gravallese Ellen M.,
Baker Nancy,
Lester Susan,
Kay Jonathan,
Owen William F.
Publication year - 1992
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780350518
Subject(s) - amyloidosis , beta 2 microglobulin , medicine , pathogenesis , complication , disease , chronic renal failure , amyloid (mycology) , dialysis , intensive care medicine , pathology
The cases presented illustrate some of the typical (case 1) and less common (case 2) clinical features of beta 2m amyloidosis. The accumulation of beta 2m amyloid in tissues is a potentially severe complication of dialysis-treated chronic renal failure. Beta 2m amyloidosis has been shown to have distinct clinical, radiologic, and pathologic features. The pathogenesis of this condition is not yet clearly understood, and recommendations for the clinical management of these patients at present are limited to recognition of the disease and symptomatic treatment. Further insights into the biology of this disease should lead to new strategies for prevention and treatment.