Open AccessInduction of arthritis in rats by soluble peptidoglycan‐polysaccharide complexes produced by human intestinal flora
Author(s) -
Kool Jeanette,
RuselerVan Embden Johanneke G. H.,
Van Lieshout Leo M. C.,
De Visser Hendrik,
GerritsBoeye Marjolein Y.,
Van Den Berg Wim B.,
Hazenberg Maarten P.
Publication year - 1991
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780341222
Subject(s) - peptidoglycan , polysaccharide , microbiology and biotechnology , arthritis , flora (microbiology) , chemistry , bacteria , biology , cell wall , biochemistry , immunology , genetics
Peptidoglycan‐polysaccharide complexes were isolated from feces of a healthy subject and from ileostomy fluid from 5 patients. Peptidoglycan‐polysaccharide complexes were tested for arthritogenicity in a rat model, by subcutaneous injection in Freund's incomplete adjuvant. Complexes from the healthy subject did not induce arthritis, but those from ileostomy fluid of 1 of the patients induced severe, chronic joint inflammation. We concluded that peptidoglycan‐polysaccharide complexes from intestinal flora are potentially arthritogenic in rats. This arthritogenicity may be influenced by the content of muramic acid and rhamnose in these complexes.