Open AccessImmunoglobulin heavy chain constant‐region gene polymorphism in systemic lupus erythematosus
Author(s) -
Kumar Ashok,
MartinezTarquino C.,
MariaForte A.,
Kumar Priti,
AlarconSegovia D.,
Granados J.,
Pandey J. P.,
Buxbaum J.,
Schur Peter H.
Publication year - 1991
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780341212
Subject(s) - antibody , restriction fragment length polymorphism , immunoglobulin heavy chain , immunology , lupus erythematosus , gene , polymorphism (computer science) , genotype , restriction fragment , immunoglobulin g , biology , genetics
Abstract Systemic lupus erythematosus (SLE) is associated with immunoglobulin allotypes in several ethnic groups. In this study, we investigated the association of a Bst EII immunoglobulin heavy chain constant‐region gene restriction fragment length polymorphism with SLE in patients from the US and Mexico. A 3‐kb restriction fragment was observed with significantly decreased frequency in randomly selected Mexican SLE patients and in Mexican SLE patients in multiplex families. However, no such association was observed in SLE patients from the US. Thus, the absence of a 3.0‐kb Bst EII restriction fragment from immunoglobulin heavy chain constant‐region genes provides a marker for SLE in Mexican individuals.