Open AccessAspirin alters methotrexate disposition in rheumatoid arthritis patients
Author(s) -
Stewart Clinton F.,
Fleming Ronald A.,
Germain Bernard F.,
Seleznick Mitchel J.,
Evans William E.
Publication year - 1991
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780341207
Subject(s) - rheumatoid arthritis , medicine , methotrexate , aspirin , concomitant , arthritis , toxicity , gastroenterology , pharmacology
Intravenous methotrexate (MTX) (10 mg), either alone or with oral aspirin (ASA) (3,900 mg/day), was administered to 15 patients with rheumatoid arthritis. Systemic and renal clearance of MTX were lower, and the unbound fraction of MTX was higher when patients were also receiving ASA than when taking MTX alone. No acute hematologic, renal, or hepatic toxicity was observed with either treatment. The findings of this study therefore indicate that concomitant aspirin therapy acutely alters the clearance of low‐dose MTX in patients with rheumatoid arthritis.