Open AccessSuppression of type II collagen–induced arthritis by monoclonal antibodies
Author(s) -
Kobayashi Seiichi,
Terato Kuniaki,
Harada Yoshitada,
Moriya Hideshige,
Taniguchi Masaru
Publication year - 1991
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780340108
Subject(s) - cyanogen bromide , monoclonal antibody , type ii collagen , epitope , arthritis , antibody , type i collagen , chemistry , microbiology and biotechnology , peptide , collagen induced arthritis , immunization , immunology , medicine , endocrinology , biology , peptide sequence , biochemistry , gene
Some mouse monoclonal antibodies raised against chicken type II collagen suppressed or delayed the onset of chicken type II collagen–induced arthritis in DBA/1 mice. This was correlated with the suppression of anti–mouse type II collagen antibody responses following immunization with chicken type II collagen. The epitopes recognized by the suppressive antibodies were found to be present on cyanogen bromide (CB)—digested collagen peptides CB‐11 and CB‐12. This was also confirmed by the finding that administration of the CB‐11 or CB‐12 peptide suppressed the induction of arthritis.