Relationship of glucocorticoid dosage to serum bone gla‐protein concentration in patients with rheumatologic disorders | Zendy

Kotowicz Mark A. | Zendy; Hall Stephen | Zendy; Hunder Gene G. | Zendy; Cedel Sandra L. | Zendy; Mann Kenneth G. | Zendy; Riggs B. Lawrence | Zendy

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Relationship of glucocorticoid dosage to serum bone gla‐protein concentration in patients with rheumatologic disorders

Author(s) -

Kotowicz Mark A.,

Hall Stephen,

Hunder Gene G.,

Cedel Sandra L.,

Mann Kenneth G.,

Riggs B. Lawrence

Publication year - 1990

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/art.1780331005

Subject(s) - prednisone , dose , creatinine , medicine , endocrinology , glucocorticoid , serum concentration , gastroenterology

Serum bone Gla‐protein (BGP) measurements in 50 rheumatic disease patients receiving long‐term prednisone therapy revealed an inverse relationship (r = −0.71, P < 0.001) between serum BGP levels and prednisone dosage. Multiple regression analysis demonstrated significant relationships (R 2 = 0.72, P < 0.001) between serum BGP 1/2 and prednisone dosage, dosage 2 , serum creatinine, age, and an age‐creatinine interaction. This model predicts the suppression of serum BGP with low dosages of steroids and 50% suppression with dosages of 20–25 mg/day.

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