Open AccessSequence of i‐e genes from autoimmune new zealand white mice
Author(s) -
Smith Lawrence R.,
Theofilopoulos Argyrios N.
Publication year - 1990
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780330418
Subject(s) - major histocompatibility complex , gene , white (mutation) , biology , autoimmune disease , genetics , immunology , systemic lupus erythematosus , antigen , histocompatibility , human leukocyte antigen , disease , antibody , medicine
Autoimmune New Zealand white (NZW) mice contribute to (New Zealand black × New Zealand white)F 1 mice 1 or more major histocompatibility complex‐linked genes that strongly correlate with susceptibility to murine lupus. The NZW class II major histocompatibility complex genes, I‐Eα and I‐Eβ, were cloned and sequenced and found to differ from normal B10.PL (H‐2 u ) mice by 3 amino acids in the first domain of the I‐Eβ subunit. Of these differences, the arginine at position 72 of NZW mice could be an important disease determinant since it lies in a predicted antigen‐binding cleft.