Open AccessLy‐1 b cells and disease activity in (new zealand black × new zealand white)f 1 mice
Author(s) -
Carmen Fariñas M.,
Stall Alan M.,
Solovera Jose J.,
Tarlinton David M.,
Herzenberg Lenore A.,
Strober Samuel
Publication year - 1990
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780330413
Subject(s) - cd5 , antibody , b cell , immunology , population , secretion , white (mutation) , lymphatic system , autoimmune disease , biology , microbiology and biotechnology , medicine , endocrinology , gene , genetics , environmental health
The treatment of female (New Zealand black × New Zealand white)F 1 mice with total lymphoid irradiation resulted in a prolonged remission of autoimmune disease activity. Total lymphoid irradiation‐treated mice also showed a marked reduction of Ly‐1 B cells, which lasted up to 3 months. The subsequent return of Ly‐1 B cells to preirradiation levels was not associated with a simultaneous return of disease when measured by parameters such as IgG anti‐DNA antibodies and spontaneous secretion of IgG by splenic cells. In cell sorting experiments, most of the cells spontaneously secreting IgG were found within the Ly‐1‐ (CD5‐) splenic B cell population.