Open AccessC3 activation products correlate with antibodies to lipid a in pauciarticular juvenile arthritis
Author(s) -
Olds Lynne C.,
Miller John J.
Publication year - 1990
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/art.1780330409
Subject(s) - antibody , arthritis , immunology , titer , juvenile , medicine , complement system , lipid a , systemic lupus erythematosus , biology , disease , genetics , lipopolysaccharide
IgM antibodies to monophosphoryl‐lipid A were found to be elevated in sera from children with all forms of juvenile arthritis (JA) and systemic lupus erythematosus. Of more interest, in patients with pauciarticular JA, IgG antibody titers to monophosphoryl‐lipid A were found to be correlated with the C3a concentration and the C3d:C3 ratio. Although the full specificity of these antibodies is unknown, they are the first that have been found to be correlated with complement activation products in any form of JA.